Abstract
Abstract The combination reaction of Japp–Klingemann reaction and Fischer indole synthesis, involving the condensation between aryldiazonium salt and an active methylene or methinyl compound under acidic or basic conditions to form a hydrazone derivative followed by cyclization to give a substituted indole is referred to as the Japp–Klingemann Fischer indole protocol. The study finds that in this reaction involvement of the elelctrophilic attack of an aryldiazonium cation on the enol carbon atom of an active methinyl compound to give an azo intermediate. This reaction has been applied for the preparation of indole derivatives.
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