Abstract
The Hisayama Study is a population-based prospective cohort study designed to evaluate the risk factors for lifestyle-related diseases, such as stroke, coronary heart disease, hypertension, diabetes, and dementia, in a general Japanese population. The prospective follow-up surveys have been conducted in subjects aged 40 or older since 1961. Notable characteristics of this study include its high participation rate (70–80% of all residents aged 40 or older), high follow-up rate (99% or over), and high autopsy rate (approximately 75% of deceased cases). The Hisayama Study has provided valuable evidence of secular change in the prevalence and incidence of several lifestyle-related disease and their risk factors. The study has thereby contributed to elucidation of the preventive strategies for lifestyle-related disease. Research efforts in this cohort are ongoing and will provide additional data for the improvement of human health and longevity.
Highlights
The Hisayama Study is a population-based prospective cohort study designed to evaluate the risk factors for lifestyle-related diseases, such as stroke, coronary heart disease, hypertension, diabetes, and dementia, in a general Japanese population
The Hisayama Study is a population-based prospective cohort study that has been conducted in the town of Hisayama, Japan since 1961 and is still ongoing
At the time of the study launch, the reliability of the diagnosis of stroke subtypes based on physical examinations and death certificates in classifying disease was not very certain in the absence of postmortem examinations, because imaging diagnosis methods—namely, computed tomography (CT) and magnetic resonance imaging (MRI) scans—had not yet been developed
Summary
The Hisayama Study is a population-based prospective cohort study that has been conducted in the town of Hisayama, Japan since 1961 and is still ongoing. The Hisayama Study was initiated in order to clarify certain doubts regarding national mortality statistics for the Japanese population. The Hisayama Study was initiated by Professor Shibanosuke Katsuki, who led the 2nd Department of Internal Medicine, Kyushu University ( the Department of Medicine and Clinical Science, Graduate School of Medical Sciences), in order to elucidate the accurate incidence and mortality of stroke and its subtypes in a community-dwelling Japanese population. At the time of the study launch, the reliability of the diagnosis of stroke subtypes based on physical examinations and death certificates in classifying disease was not very certain in the absence of postmortem examinations, because imaging diagnosis methods—namely, computed tomography (CT) and magnetic resonance imaging (MRI) scans—had not yet been developed. The results based on autopsy data demonstrated that the mortality from brain hemorrhage was only about 1.1-times higher than that of brain infarction, and misdiagnosis on death certificates was not as uncommon as previously thought.
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