Abstract
An outbreak of viral encephalitis occurred in Gorakhpur, India, from July through November 2005. The etiologic agent was confirmed to be Japanese encephalitis virus by analyzing 326 acute-phase clinical specimens for virus-specific antibodies and viral RNA and by virus isolation. Phylogenetic analysis showed that these isolates belonged to genogroup 3.
Highlights
An outbreak of viral encephalitis occurred in Gorakhpur, India, from July through November 2005
We report in-depth investigations of Japanese encephalitis virus (JEV)-specific antibodies, virus isolation, and demonstration of viral RNA in 326 febrile patients with encephalitis symptoms who were admitted to B.R.D
The dendrogram showed that the JEV isolates responsible for the 2005 Gorakhpur epidemic belong to genogroup 3 (G3) but form a cluster separate from earlier Indian isolates (Figure)
Summary
An outbreak of viral encephalitis occurred in Gorakhpur, India, from July through November 2005. We report in-depth investigations of JEV-specific antibodies, virus isolation, and demonstration of viral RNA in 326 febrile patients with encephalitis symptoms who were admitted to B.R.D. Medical College, Gorakhpur. Further molecular epidemiologic studies were performed to establish the genetic relatedness of the viral strain associated with this epidemic. The Study A total of 326 clinical samples (185 blood and 141 cerebrospinal fluid [CSF]) were collected from the 326 patients who had a diagnosis of encephalitis.
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