Abstract

In 2017, the Japan Society of Clinical Oncology (JSCO) published the JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were the first Japanese guidelines to address issues of oncofertility. In this field of medicine, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment. These JSCO guidelines were intended to guide multidisciplinary medical staff in considering the availability of fertility preservation options and to help them decide whether to provide fertility preservation to childhood, adolescent, and young adult cancer patients before treatment starts, with the ultimate goal of improving patient survivorship. The guidelines are presented as Parts 1 and 2. This article (Part 1) summarizes the goals of the guidelines and the methods used to develop them and provides an overview of fertility preservation across all oncology areas. It includes general remarks on the basic concepts surrounding fertility preservation and explanations of the impacts of cancer treatment on gonadal function by sex and treatment modality and of the options for protecting/preserving gonadal function and makes recommendations based on 4 clinical questions. Part 2 of these guidelines provides specific recommendations on fertility preservation in 8 types of cancer (gynecologic, breast, urologic, pediatric, hematologic, bone and soft tissue, brain, and digestive).

Highlights

  • Goal of the Japan Society of Clinical Oncology GuidelinesIn childhood, adolescent, and young adult (CAYA) cancer patients, increasing attention is being paid to fertilityExtended author information available on the last page of the article preservation before the start of cancer treatment, with the aim to improve patients’ survivorship

  • In the field of oncofertility, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment

  • Several national and international guidelines have been issued for fertility preservation in cancer patients, including the American Society of Clinical Oncology (ASCO) 2006 Guidelines, which recommend that health care providers caring for cancer patients should inform them before treatment starts about the possibility of infertility, consider using any fertility preservation option available for eligible patients and refer such patients and/or their families to reproductive specialists [1]

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Summary

Introduction

Adolescent, and young adult (CAYA) cancer patients, increasing attention is being paid to fertility. Several national and international guidelines have been issued for fertility preservation in cancer patients, including the ASCO 2006 Guidelines, which recommend that health care providers caring for cancer patients should inform them before treatment starts about the possibility of infertility, consider using any fertility preservation option available for eligible patients and refer such patients and/or their families to reproductive specialists [1]. This section discusses these methods in more detail below and addresses the acceptable time to consider pregnancy after completion of cancer chemotherapy and the optimal timing of oocyte/ovarian tissue harvesting. Breast cancer, lymphoma, digestive system cancer, gynecological cancer, malignant melanoma, germ cell tumor, brain tumor, sarcoma, etc

Method for freezing
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60. National Institute for Health and Clinical Excellence
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