Abstract
Kastenbauer et al. observed increased tyrosine nitration (a marker for peroxynitrite) 4-HNE staining in the leptomeninges, and inflammatory cells of a bacterial meningitis patient. in the brain and CSF of patients with acute bacterial meningitis. Increased CSF nitrotyrosine concentrations were associated with a depletion of ascorbate, an increased oxidation of the natural peroxynitrite scavenger uric acid, and an adverse outcome of meningitis. see page 186 The accompanying editorial by Simon and Beckman points out that the cause of the encephalopathy of meningitis remains unclear. CSF and brain pathology does not reflect the severity of the clinical picture. A diffusable toxin is likely and the Kastenbauer …
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