Abstract
Plants produce a wide spectrum of secondary metabolites that play critical roles in plant-environment interactions and against biotic and abiotic stresses. Moreover, many secondary metabolites have pharmaceutical efficacy for a wide range of diseases (cancer, malaria, etc.). Controlled transcription of biosynthetic genes is one of the major mechanisms regulating secondary metabolism in plants. Several transcription factor families such as MYC, MYB, WRKY and AP2/ERF have been found to be involved in the regulation of secondary metabolism in different medicinal plants. In addition, the biosynthesis and proper accumulation of secondary metabolites are also induced by signaling molecule jasmonic acid (JA). This review provides an insight into JA signaling pathway and JA-mediated transcriptional regulation of secondary metabolism (vinblastine, nicotine, artemisinin, taxol and ginsenoside) in a range of medicinal plant species.
Highlights
Plants produce a variety of low molecular weight organic compounds that are usually ramified into two large classes: primary and secondary metabolites
This review provides an insight into jasmonic acid (JA) signaling pathway and JA-mediated transcriptional regulation of secondary metabolism in a range of medicinal plant species
The JA ZIM domain (JAZ) proteins are further characterized by a Jas domain that is required for the interaction of both CORONATINE INSENSITIVE 1 (COI1) and a broad array of transcription factors (TFs) [14, 15]
Summary
Plants produce a variety of low molecular weight organic compounds that are usually ramified into two large classes: primary and secondary metabolites. JAs act as ubiquitous and conserved elicitors for the production of secondary metabolites across the plant kingdom, from gymnosperms to angiosperms [10, 11]. The promising depiction of transcriptional regulation of secondary metabolism suggests that, in response to phytohormones (JAs), TFs form dynamic regulatory networks that fine-tune the timing, amplitude and tissue-specific expression of pathway genes and the subsequent accumulation of secondary metabolites [8]. We give an updated review on JA-responsive signaling pathway and speculate on JA-mediated transcriptional regulation of secondary metabolism (e.g., vinblastine, nicotine, artemisinin, taxol and ginsenoside) in a range of medicinal plant species
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