JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics.

Abstract

TO THE EDITOR: The JAK2 V617F mutation is the most common somatic mutation in the classical myeloproliferative neoplasms (MPNs), present in >95% of cases of polycythemia vera (PV) and ∼50% of essential thrombocythemia (ET) and myelofibrosis (MF).[1][1][⇓][2][⇓][3]-[4][4] It is usually the