Abstract
High power decompression unit of an autonomous drug release system based on chemo-mechanical energy conversion was developed. The decompression unit was fabricated by separating a cylindrical cell into a top cell (gas phase) and a bottom cell (liquid phase) by glucoseoxidase (GOD) enzyme immobilized membrane. The enzyme membrane recognizes glucose and converts chemical energy found in glucose to mechanical energy. In this study, the decompression unit increased membrane area per cell volume (0.73 ・ 3.00 cm2/m1) was fabricated in order to drive by lower glucose concentration. As a result, the improved cell connected to pressure release valve was successfully driven by 25 mM glucose solution (a conventional cell was driven by 100 mM). The possibility of autonomous drug release systems to control the patient's own blood sugar levels was suggested.
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