J052021 衝撃波DDS開発のための圧力波によるマイクロカプセルと気泡変形挙動の観察([J05201]ドラッグデリバリーシステムでの流動現象とデバイス開発(2))

Abstract

This paper describes the fundamental investigations for developing new technology using pressure waves and bubbles such as drug delivery systems (DDS). The microcapsules made of lipid including gas bubble were made by controlling ultrasound and gas flow rate. We examined the effect of ultrasound intensity and gas flow on particle diameter and diameter ratio of gas-liquid. Also, effects of working pressure amplitude and mechanical index on disintegration efficiency of capsule were examined. As a result, there are possibilities to disintegrate microcapsules efficiently by controlling pressure amplitude and frequency.