Abstract
Fabrication of very porous scaffold for regeneration of organs with high metabolic rate is reported. Polycaprolactone (PCL) powder was mixed with sodium chloride powder and SLS (Selective Laser Sintering) processed to develop an object including fine flow channel network. This sinter was rinsed with water to desolve the salt, and a high porosity of 90% was successfully obtained. In addition, unsintered powder in the channels was effectively removed owing to disappearance of the filler. Through micro-CT observation, it was confirmed that channels of which diameter was smaller than 1mm were fabricated. Cell culture test using human hepatoma cells was performed and advantage of using this scaffold was shown. Hydroilizing treatment with oxygen plasma was performed, and its effect is tested by cell culture of endothelial cells.
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