Abstract
Aiming at establishing a simulation-based framework for predictive medicine we have developed a patient-specific aortic aneurysm model based on computational biomechanics. In this study, we construct two image-based three-dimensional patient-specific models of aortic aneurysms based on CT images of two patients. A multi-scale hemodynamic model is employed to couple these three-dimensional models with a closed-loop 0-1-dimension hemodynamic model for the whole cardiovascular system. The aortic aneurysm hemodynamics are then visualized in terms of streamlines, wall shear stresses and oscillatory shear index, and further analyzed with a specific focus on the relationship between the hemodynamics and the occurrence of the aortic aneurysm.
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