Abstract
Johnson & Johnson is tapping Arrowhead Pharmaceuticals to license its experimental RNA interference (RNAi) therapy for the hepatitis B virus. Arrowhead will receive a $75 million equity investment and $175 million up front from J&J, and depending on how the RNAi therapy performs—currently in a Phase I/II study—Arrowhead could earn up to $1.6 billion in milestone payments. Finally, J&J may work with Arrowhead to develop three more RNAi therapies against additional targets, with $1.9 billion in potential milestone payments.
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