Şizofreni Hastalarında Gözün Arka Segment Yapılarının Değerlendirilmesi

Abstract

Purpose: We aimed to evaluate the effects of schizophrenia on posterior ocular structures including the retinal nerve fiber layer (RNFL), central macular thickness (CMT), choroidal thickness (CT) and lamina cribrosa (LC) measurements.Methods: A total of 35 patients with schizophrenia and 35 healthy individuals were enrolled. Only the right eye of each participant was tested. RNFL thickness in all quadrants, CT, CMT, LC thickness, and LC depth (LCD) measurements were performed using Fourier domain optic coherence tomography (OCT), and each variable was compared between groups.Results: The mean age and sex distributions were similar between groups (p=0.528 and p=0.299, respectively). The average, superior, inferior, nasal, and temporal RNFL thicknesses were significantly lower in schizophrenia patients than in controls (p<0.001, p<0.001, p=0.001, p=0.002 and p<0.001, respectively). The mean subfoveal and perifoveal CT were not significantly different between the groups (subfoveal; p=0.676, 1.5 mm nasal; p=0.632, 3 mm nasal; p=1.000, 1.5 mm temporal; p=0.811, 3 mm temporal; p=0.145). The mean CMT was similar among the groups (p=0.678). LC thickness and LCD were not statistically significant between groups (p=0.816 and p=0.161).Conclusions: We demonstrated that RNFL thicknesses in all quadrants were significantly lower in schizophrenia patients than in control subjects. However, there were no significant differences in the CMT, perifoveal and subfoveal CT, LC thickness, and LCD between the groups. These results suggest that OCT can be used to image neuronal loss by evaluating the RNFL in patients with schizophrenia. Keywords: Schizophrenia; retinal nerve fiber layer; choroidal thickness; lamina cribrosa thickness; macular thickness