Abstract
A systematic review of randomized controlled trials (RCTs) was conducted to investigate how Zn intake influences plasma/serum Zn concentrations. We used protocols developed by EURRECA to perform a literature search for papers published up until February 2010 through MEDLINE, EMBASE, and Cochrane Library CENTRAL. We extracted data from studies that investigated apparently healthy adults and elderly, and conducted the metaanalysis using STATA (11.0). The relationship between Zn intake and plasma/serum Zn concentrations following intervention was expressed as a regression coefficient (beta), i.e., the gradient of the response curve expressed on a natural log scale. The final metaanalysis included 31 data sets from 15 RCTs. Pooled data revealed a significant relationship between Zn intake and plasma/serum Zn concentrations with an overall beta value of 0.14 (95% CI 0.11-0.18, P
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