Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche

Abstract

Depolarization by the neurotransmitter GABA regulates adult neurogenesis. Here we show that interneurons of the neurogliaform cell family are a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurs in concert with reduced synaptic inhibition of mature neurons, suggesting the local circuitry facilitates coordinated activation of new and pre-existing cells.