Abstract
Ivermectin 10 mg/g cream (Soolantra®) is an effective and well tolerated option for the once-daily treatment of inflammatory papulopustular rosacea lesions in adults. The beneficial effects of ivermectin on inflammatory rosacea lesions is assumed to be linked to ivermectin’s anti-inflammatory properties and ability to cause the death of Demodex mites, which may contribute to skin inflammation. In patients with moderate to severe inflammatory lesions of papulopustular rosacea, treatment with ivermectin cream significantly improved treatment success rates, inflammatory lesion counts and health-related quality of life measures relative to the cream vehicle, and relative to metronidazole cream in short-term trials. Ivermectin cream is also associated with significantly longer periods of remission and lower rates of relapse after initial treatment success than metronidazole cream. Rosacea continued to improve with long-term ivermectin therapy in extension studies.
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