Abstract
In treating human immunodeficiency virus (HIV)— associated eosinophilic folliculitis (EF), potent topical steroids, systemic corticosteroids, antihistamines, and UV light phototherapy (including psoralen plus UV-A) exhibit therapeutic benefit.<sup>1-3</sup>An open trial of itraconazole for EF was undertaken following anecdotal reports from physicians in Europe that it dramatically improved HIV-associated pruritus. <h3>Patients and Methods.</h3> Twenty-eight patients were entered in the study at two centers: the private practice of one of us (M.C.) (<i>center 1</i>) and the dermatology clinics of the University of California—San Francisco (<i>center 2</i>). At center 1, if the history and physical findings were compatible with eosinophilic folliculitis, skin biopsies were performed and itraconazole therapy (200 mg twice a day) was immediately begun. Eleven of 12 patients who underwent a biopsy had EF. At center 2, after histologically confirming the diagnosis, treatment was begun. The first three patients received a dose of 100 mg/d. Thereafter, the initial dose was
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