Itraconazole for leukemia complicating with invasive fungal infection

Abstract

Objective To explore the clinical efficacy of itraconazole for leukemia complicating with invasive fungal infection.Methods 149 leukemia patients complicating with fungal infections in our hospital were enrolled from August 2007 to September 2011,and divided them into control group (n =74) and observation group (n=75) according to the antifungal agents they chose.The control group were treated with fluconazole,400 mg/d,and the observation group were treated with itraconazole,200 mg/d.Clinical efficacy and adverse reactions were compared between these two groups.Results The cured rate,effective rate and total effective rate were 48.0％,20.0％,94.6％ in the observation group,respectively,which were significantly higher than that in the control group (32.4％,16.2％,77.0％) (P＜0.05).No serious adverse reactions occurred in both groups during the treatment.The main adverse reaction was liver function abnormality after medication;the occurrence was 16.2％ in the control group patients and 21.3％ in the observation group,without significant difference (P＞ 0.05).Conclusions Itraconazole for leukemia complicating with invasive fungal infection is clinically efficacious,safe,and should be clinically generalized. Key words: Itraconazole; Leukemia; Fungal infection; Clinical efficacy