ITG and SEL Genes Polymorphisms Associated with Bronchial Asthma, Complications of Peripheral and Coronary Atherosclerosis, and Mammary Adenocarcinoma among Residents of the Republic of Adygea

Abstract

In the structure of causes of death in the Republic of Adygea (RA), cardiovascular (CVD) and cancerous diseases have traditionally been for many years in the first place. The relevance of the study is determined by the search for early molecular genetic markers of multifactorial diseases. The distribution of Single Nucleotide Polymorphisms (SNP) of genes of adhesion molecules of integrins ITG (ITGA2 C807T, rs1126643, ITGB3 Leu33Pro, rs5918), selectins SEL (SELE Leu554Phe, rs5355; Ser128Arg, rs5361, SELP Thr715Pro, rs6136) in the residents of RA has been studied by the SNP-method in 44 DNA samples of donors (n = 10) and patients (n = 34) who had CVD (n = 17), Malignant Neoplasms (MN) (mammary adenocarcinoma, n = 8), and chronic inflammatory lung diseases (bronchial asthma – BA), n = 9). The 128Arg polymorphism of the SELE gene - endothelial E-selectin (χ² = 6.66, p = 0.01; OR = 15) and platelet P-selectin SELP Thr715Pro (χ² = 4.55; p = 0.03; OR = 7) are statistically significantly associated with systemic pathological processes. Carriage of the pathological homozygous genotype Arg128Arg and “mutant” SELE allele 128Arg is associated mainly with peripheral (respectively, χ² = 12.31; p = 0.002; OR = 39; χ² = 21.96; p = 0.000003, OR = 100) and less with coronary atherosclerosis (χ² = 4.09, p = 0.04; OR = 10). The molecular and genetic predictor of ischemic and hemorrhagic stroke is the carriage of the 715Pro allele of the SELP gene (χ² = 7.54, p = 0.006; OR = 17).