Abstract
Using the recommended modifications to isothermal titration calorimetry (ITC) analysis proposed by Turnbull and Daranas (J. Am. Chem. Soc. 2003, 125 14859–14866) and Tellinghuisen (Anal. Biochem. 2008, 373, 395–397), we determine the thermodynamic data for the binding of a series of halogenated guests to deep-cavity cavitand 1. These modifications allowed the accurate determination of the thermodynamic data of systems with c values of between 0.2 and 5; values that are much lower than is often suggested as the lower limit of ITC. The compiled data allowed a more accurate glimpse of the strength of the unusual C–H…X–R hydrogen bonds observed between these hosts and halogenated guests.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
