Abstract
Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).
Highlights
The medical committee (>5 years of experience) comprises allergists/allergologists, dermatologists, rheumatologists, anesthesiologists, dentists and otorhinolaryngologists whereas the non-medical experts are biologists with at least five publications focusing on Multiple chemical sensitivity (MCS) in peer-reviewed international journals in the last five years (Table 2)
We reported in the results section only statements that achieved an agreement
During the pre-Delphi, the results of the systematic review were collegially discussed among six stakeholders but no agreement was reached
Summary
Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population [1].
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