Abstract
Male factor infertility accounts for 40-50% of infertility among couples seeking assisted reproductive technology (ART). Research on a new parameter of sperm quality, known as DNA fragmentation, suggests that fragmentation rates >27% may hinder embryo development and increase rates of miscarraige, while lower fragmentation rates are associated with improved outcomes. Recently, microfluidic sperm sorting as a sperm selection method has shown to decrease DNA fragmentation rates by positively selecting healthy sperm, compared to the standard method of density gradient centrifugation.
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