Abstract
More than 5 million children in the United States attend out-of-home chhild care centers. Treatment of bacterial infections with antibiotics can be complicated for these children. Results from a study comparing the efficacy and safety of azithromycin and amoxicillin/clavulanate in children with otitis media in child care or school settings demonstrated that azithromycin was as effective as, but significantly better tolerated than, amoxicillin/clavulanate. Responses to a structured questionnaire and parent interview showed that azithromycin was convenient to administer and well accepted by parents and children. Treatment duration, dosage interval, taste and other convenience issues affect compliance in day-care settings and thus have an impact on clinical outcome. The parental and patient acceptance of azithromycin combined with its convenient once daily, 5-day treatment schedule addresses these issues and contributes to successful clinical outcomes in children with otitis media in child care settings
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