Issue Information

Abstract

Journal of NeurochemistryVolume 165, Issue 6 p. 757-758 ISSUE INFORMATIONFree Access Issue Information First published: 22 June 2023 https://doi.org/10.1111/jnc.15634 Read the full article: ‘Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory’ by R. Martínez-Mármol, Y. Chai, J. N. Conroy, Z. Khan, S.-M. Hong, S. B. Kim, R. S. Gormal, D. H. Lee, J. K. Lee, E. J. Coulson, M. K. Lee, S. Y. Kim, and F. A. Meunier (J. Neurochem. vol. 165 (6), pp. 791–808) on doi:10.1111/jnc.15767 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Front cover The traditional medicinal mushroom Hericium erinaceus, also known as lion’s mane mushroom has bioactive compounds with neurotrophic activity. Here, we purified and identified biologically active molecules isolated from H. erinaceus, based on their ability to promote neurite extensive outgrowth in hippocampal neurons. We found that N-de phenylethyl isohericerin (NDPIH) and its hydrophobic derivative hericene A, were highly potent in inducing neurite outgrowth and branching in cultured hippocampal neurons. In addition, mice feed with hericene A showed both increased BDNF signaling and enhanced hippocampal memory performance. Biochemical analysis revealed that the aforementioned neurotrophic effects are independent but convergent to BDNF/TrkB pathway. Our results reveal potent bioactive compounds derived from H. erinaceus. These molecules are very attractive compounds for their neurotrophic properties. Our findings open the door to identifying novel mushroom-derived compounds as an strategy for the development of sustainable therapeutical interventions to revert the cognitive decline associated with ageing and neurodegenerative diseases. Image content Confocal image of a giant growth cone from an hippocampal neuron elicited by NDPIH. Immunocytochemistry against tubulin (mouse anti-βIII tubulin primary antibody, and Alexa FluorTM 488-goat-anti-mouse secondary antibody, green) and actin (Alexa-FluorTM 647-phalloidin, magenta). Read the full article ‘Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory’ by R. Martínez-Mármol, Y. Chai, J. N. Conroy, Z. Khan, S.-M. Hong, S. B. Kim, R. S. Gormal, D. H. Lee, J. K. Lee, E. J. Coulson, M. K. Lee, S. Y. Kim, and F. A. Meunier (J. Neurochem. vol. 165 (6), pp. 791–808) on doi:10.1111/jnc.15767 Volume165, Issue6June 2023Pages 757-758 RelatedInformation