Abstract
Maternal excessive folic acid intake induced hyperactivity and a low anxiety state, whereas maternal undernutrition led to hypoactivity. Furthermore, brain monoamine profiles in offspring were transformed by excessive maternal folic acid fortification and undernutrition in different directions. Excessive maternal folic acid fortification and undernutrition may alter offspring behavior through additive or synergistic effects on brain monoamine profiles. Further details can be seen in the article by Ono et al. in this issue.This study is dedicated to Mr. Kodai Hino, who passed away in 2018 after accomplishing its main experiments with us. image
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