Abstract
Front cover: The node forming transiently in mammalian embryos plays a key role in left‐right axis determination. The node is a cavity, in which crown cells with immotile cilia surround pit cells that rotate their motile cilia to generate a leftward fl uid fl ow (nodal fl ow). Experiments using GCaMP6, which emits green fl uorescence in response to Ca2+, and optical tweezers revealed that immotile cilia sense mechanical force generated by nodal fl ow (Katoh et al. (2023) Science 379: 66–71, DOI: 10.1126/science.abq8148). A similar mechanism was shown to exist in zebrafi sh (Djenoune et al. (2023) Science 379: 71–78, DOI: 10.1126/science.abq7317). This picture shows the application of this mechanism to ‘hiburi‐ryo’ (fishing by using flames to drive fish). The fishermen in the pond are creating a leftward current to be sensed by the men on the left bank, who are activated, and their torch flames intensify. Designed by TRAIS Co., Ltd. (Kobe, Japan).image
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