Issue Information – Cover

Abstract

Microbiology and ImmunologyVolume 67, Issue 5 p. i-ii COVER IMAGEFree Access Issue Information – Cover First published: 02 May 2023 https://doi.org/10.1111/1348-0421.12995AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Cover photograph: (1) The role of γδ T cells in skin is still unknown. Do they interact with sporozoite? Do they able to kill sporozoite or facilitate DC to recognize and phagocytize sporozoite? Lots to be answered in the future. (2) The responses of γδ T cells during liver-stage are mainly protective. Studies of attenuated sporozoite vaccination showed activation and expansion of γδ T cells. These γδ T cells produce large amount of IFN-γ and were able to protect subsequent challenge infection in human. γδ T cells are involved in activation and maturation of DC, and they may facilitate recruitment of inflammatory cells in the liver. γδ T cells also contribute to the activation and accumulation of CD8+ T cells directly or through DC. (3) Protective and pathogenic roles of γδ T cells during blood-stage have been proposed. Upon activation γδ T cells produce pro-inflammatory cytokines which enhance APC cells maturation. Also they are involved in accumulation and activation of myeloid cells by producing M-CSF. They can present antigens to naïve γδ T cells and initiate adaptive immune response. Moreover, γδ T cells facilitate antibody production and germinal center formation either directly contacting with B cells or through T follicular helper cells. In vitro studies of human γδ T cells showed capacity of antigen presentation, phagocytosis and cytotoxicity. However, these functions should be investigated in the tissue or in vivo. Microbiol Immunol: 67:239–247. Article link here Volume67, Issue5May 2023Pages i-ii RelatedInformation