ISSUE HIGHLIGHTS

Abstract

IUBMB LifeVolume 72, Issue 4 p. 523-523 ISSUE HIGHLIGHTSFree Access ISSUE HIGHLIGHTS First published: 11 March 2020 https://doi.org/10.1002/iub.2243AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 706 Association between dietary inflammatory index and risk of cardiovascular disease in the Mashhad stroke and heart atherosclerotic disorder study population Zahra Asadi, Mahdiyeh Yaghooti-Khorasani, Hamideh Ghazizadeh, Fatemeh Sadabadi, Ehsan Mosa-Farkhany, Susan Darroudi, Niloofar Shabani, Atiyeh Kamel-khodabandeh, Afsane Bahrami, Mohammad-Sadegh Khorrami-Mohebbseraj, Sahar Heidari-Bakavoli, Alireza Heidari-Bakavoli, Habibollah Esmaily, Mohsen Moohebati, Mohammad R. Oladi, Nitin Shivappa, James R. Hébert, Gordon A. Ferns, Majid Ghayour-Mobarhan Thedietary inflammatory index (DII®) as a novel index for evaluating the inflammatory potential of an individual's diet calculated based on the pro/anti-inflammatory macro/micro-nutrients of diet. In theMASHADcohort study population,weused a food frequency questionnaire to provide datafor calculating DII®.This cohort study showedthat thedietary intake of vegetable, fruitsand legume were higher among those with anti-inflammatory diet; while, higher dietary intake of carbohydrate beverages and processedmeat were observed in subjects with pro-inflammatory diet.The percentage ofCVDevent in subjects with pro andanti-inflammatorydietwere2.5% and 2.8%,respectivelybut werenot significant in adultsmiddle-agedof theIranianpopulation. Itmay be because the study period is partially short and there are various lifestyle factors such as diet among different ethnicities of Iranian people. Thus, future studies should be conducted in different geographic locations in theworld to confirmthese findings. 716 Neonicotinoid trapping by the FA1 site of human serum albumin Loris Leboffe, Alessandra di Masi, Viviana Trezza, Andrea Pasquadibisceglie, Gabriele Macari, Fabio Polticelli, Paolo Ascenzi Neonicotinoids are a widely used class of insecticides.Although they display a high specificity for insects, their use has been recently debated since it has been hypothesized that they may have adverse ecological effects and potential risks to mammals and even humans. Due to their hydrophobicnature,neonicotinoidsneedspecificcarrierstoallowtheirdistributioninbodyfluids. Human serum albumin (HSA), the most abundant plasma protein, is a key carrier of endogenous and exogenous compounds. In particular, HSA is essential for neonicotinoid transport and distribution to tissues and organs, including the liver where they are metabolized. 801 Regulation of lung endothelial permeability by NEK kinases Nektarios Barabutis Lung hyperpermeability is the cause and consequence of the acute respiratory distress syndrome(ARDS).Tocounteract thelethaloutcomesof this respiratorydisorder,weinvestigate the molecular cascades which regulate the pulmonary endothelial barrier function. It was recentlyrevealedthatP53inductionbytheunfoldedproteinresponseinducersgrowthhormone releasing hormone antagonists and heat shock protein 90 inhibitors; enhances endothelial barrier function. Since NEK kinases have been shown to regulate the activities of P53, it is anticipated that the stochasticmanipulation of one ormoremember(s) of this family of kinases; may deliver a promising therapeutic approach towards ARDS. REFERENCES 1Asadi, Z., Yaghooti-Khorasani, M., Ghazizadeh, H., Sadabadi, F., Mosa-Farkhany, E., et al. (2020) Association between dietary inflammatory index and risk of cardiovascular disease in the Mashhad stroke and heart atherosclerotic disorder study population. IUBMB Life 72, 706– 715. 2Leboffe, L., di Masi, A., Trezza, V., Pasquadibisceglie, A., Macari, G., et al. (2020) Neonicotinoid trapping by the FA1 site of human serum albumin. IUBMB Life. 72, 716– 723. 3Barabutis, N. (2020) Regulation of lung endothelial permeability by NEK kinases. IUBMB Life. 72, 801– 804. Volume72, Issue4Special Issue: Molecular Mechanisms of Neuronal Trafficking and Synapse Remodeling From Focused Meeting MNS 2019April 2020Pages 523-523 ReferencesRelatedInformation