ISSUE HIGHLIGHTS

Abstract

BioFactorsVolume 46, Issue 4 ISSUE HIGHLIGHTSFree Access ISSUE HIGHLIGHTS First published: 17 August 2020 https://doi.org/10.1002/biof.1672AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 502 A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A. Ferns and Majid Ghayour-Mobarhan Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta-analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D-fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta-analysis. Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: −2.772; 95% confidence interval [CI]: −5.435 to −0.109) and fasting serum insulin (MD: −2.937; 95% CI: −4.695 to −1.178) in patients with Type 2 diabetes mellitus. A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: −1.608; 95% CI: −3.138 to −0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: −0.655 to 0.069). This meta-analysis indicates that Vitamin D fortification improves indices of glycemic control. Hence, food fortified with Vitamin D may be of potential therapeutic value in diabetic patients, as an adjuvant therapy. Figure 1Open in figure viewerPowerPoint 514 New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii and Mehdi Yousefi As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long noncoding RNA (lncRNA) to prevent cancer cells through the targeting of Hippo pathways, can provide new insights into cancer target therapy. The purpose of present review, first of all, is to demonstrate the importance of Hippo signaling and its relation with other signaling pathways in cancer. It also tries to demonstrate targeting Hippo signaling progress in cancer therapy. Figure 2Open in figure viewerPowerPoint REFERENCES 1Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A. Ferns and Majid Ghayour-Mobarhan. A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices. BioFactors. 2020; 46: 502– 513. 2Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii and Mehdi Yousefi. New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors. BioFactors. 2020; 46: 514– 530. Volume46, Issue4July/August 2020 FiguresReferencesRelatedInformation