Abstract
IUBMB LifeVolume 70, Issue 6 p. 467-467 Issue HighlightsFree Access Issue Highlights First published: 28 May 2018 https://doi.org/10.1002/iub.1883AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 519 Caffeic Acid Phenethyl Ester Guards Against Benign Prostate Hypertrophy in Rats: Role of IGF-1R/Protein Kinase-B (Akt)/β-Catenin Signaling Hany A. Omar, Mai F. Tolba Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well-tolerated and effective preventive strategies to improve clinical outcomes. Caffeic acid phenethyl ester (CAPE) is an important natural active ingredient isolated from honey-bee propolis, which can guard against BPH in rats. The protection afforded by CAPE is due to its ability to counteract the abnormal increase in prostate cells' growth, in addition to opposing inflammation and oxidative stress. 553 Discriminating Gastric Cancer and Gastric Ulcer Using Human Plasma Amino Acid Metabolic Profile Fangyu Jing, Xin Hu, Yunfeng Cao, Minghao Xu, Yuanyuan Wang, Yu Jing, Xiaodan Hu, Yu Gao, Zhitu Zhu Metabonomics is a new technique for quantifying low molecular weight metabolites metabolized by organisms at specific times in specific environmental conditions. Metabolic disorders are key events in the development and progression of carcinoma, which are regarded as a hallmark of cancer. Amino acids are fundamental materials of metabolism for almost all types of cells. The alterations in amino acid metabolic profile show a correlation with gastric cancer. Our study found that the disturbed metabolic pathways of amino acids in gastric cancer patients included tricarboxylic acid cycle, urea cycle and biosynthesis of one carbon unit, which indicated that they could play certain roles in pathogenesis of gastric cancer. REFERENCES 1Omar, H A. and Tolba, M. F. Caffeic Acid Phenethyl Ester Guards against Benign Prostate Hypertrophy in Rats: Role of IGF-1R/Protein Kinase-B (Akt)/β-Catenin Signaling. IUBMB Life. 2018, 70, 519–528. 2Jing, F., Hu, X., Cao, Y., Xu, M., Wang, Y., Jing, Y. Hu, X., Gao, Y., and Zhu, Z. Discriminating Gastric Cancer and Gastric Ulcer Using Human Plasma Amino Acid Metabolic Profile. IUBMB Life. 2018, 70, 553–562. Volume70, Issue6June 2018Pages 467-467 ReferencesRelatedInformation
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