ISSUE HIGHLIGHTS

Abstract

IUBMB LifeVolume 72, Issue 5 p. 813-813 ISSUE HIGHLIGHTSFree Access ISSUE HIGHLIGHTS First published: 03 April 2020 https://doi.org/10.1002/iub.2279AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 825 Targeting vasculogenic mimicry by phytochemicals: A potential opportunity for cancer therapy Sanya Haiaty, Mohammad-Reza Rashidi, Maryam Akbarzadeh, Nazila F. Maroufi, Bahman Yousefi, Mohammad Nouri Neovascularization, Vasculogenic mimicry (VM), is regarded as the main mark of malignant cancer and has pivotal role in cancer metastasis and progression in various types of cancers. Hence, identifying compounds that target VM structures might be superior therapeutic factors for cancers treatment and controlling the recurrence and metastasis. Natural compounds especially phytochemicals including curcumin (Cur), genistein (Gen), lycorine (Lyc), luteolin (Lut), columbamine (Col) , triptolide (Tri), Paris polyphylla (Par), dehydroeffusol (DHE), jatrorrhizine hydrochloride (Jat), grape seed proanthocyanidins (Gra) , resveratrol (Res) , isoxanthohumol (Iso), dehydrocurvularine (Deh), galiellalactone (Gal), oxacyclododecindione (Oxa), brucine (Bru), honokiol (Hon), ginsenoside Rg3 (Gin), and norcantharidin (Nor) are capable of targeting VM structure in the especial signaling pathways. 884 Dysregulation of miRNAs as a signature for diagnosis and prognosis of gastric cancer and their involvement in the mechanism underlying gastric carcinogenesis and progression Alireza Ahadi Gastric cancer (GC) is one of the most frequent causes of cancer-related deaths worldwide due to its late diagnosis and poor response to treatment. Unfortunately, most tumor markers for GC lack sufficient sensitivity and specificity. Therefore, effective biomarkers are required to detect early GC and to predict tumor recurrence and chemosensitivity. Comprehensive evidence indicates that miRNAs can act as diagnosis and prognosis biomarker in GC. Thus, we provided a comprehensive review of the aberrant expression of miRNAs in GC that could act as a potential diagnosing and prognosis biomarker in GC. According to the importance of the role of miRNAs in the mechanism underlying gastric carcinogenesis and progression, we also reviewed the crosstalk between miRNAs and signaling pathways and drug-resistant in GC which can be used as important information in future studies for the treatment of GC. REFERENCES 1Sanya Haiaty, Mohammad-Reza Rashidi, Maryam Akbarzadeh, Nazila F. Maroufi, Bahman Yousefi, Mohammad Nouri. Targeting vasculogenic mimicry by phytochemicals: A potential opportunity for cancer therapy. IUBMB Life. 2020, 72, 825– 841. 2Alireza Ahadi. Dysregulation of miRNAs as a signature for diagnosis and prognosis of gastric cancer and their involvement in the mechanism underlying gastric carcinogenesis and progression. IUBMB Life. 2020, 72, 884– 898. Volume72, Issue5May 2020Pages 813-813 ReferencesRelatedInformation