Issue Highlights

Abstract

IUBMB LifeVolume 72, Issue 10 p. 2064-2064 ISSUE HIGHLIGHTSFree Access Issue Highlights First published: 21 September 2020 https://doi.org/10.1002/iub.2382AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 2080 SMARCAL1, the annealing helicase and the transcriptional co-regulator Ritu Bansal, Saddam Hussain, Upasana Bedi Chanana, Deepa Bisht, Isha Goel and Rohini Muthuswami DNA damage response and repair pathways are integral for the maintenance of genomic stability. SMARCAL1 is one of the many proteins involved in this process. SMARCAL1 uses the energy stored in ATP to remodel DNA at the site of DNA damage. It also uses this energy to activate the expression of genes required for DNA damage response pathway. Mutations in SMARCAL1 causes an autosomal recessive disorder called SIOD. In this review, we discuss the biophysical, biochemical, and functional properties of SMARCAL1. Finally, we discuss how SMARCAL1 can be used as a drug target for cancer. 2146 Role of crosstalk between STAT3 and mTOR signaling in driving sensitivity to chemotherapy in osteosarcoma cell lines Yi-tian Wang, Fan Tang, Xin Hu, Chuan-xi Zheng, Tao-jun Gong, Yong Zhou, Yi Luo and Li Min STAT3 and mTOR signaling crosstalk is critical determinant of chemosensitivity of osteosarcoma cells to Rapamycin. Crosstalk between mTOR and STAT3 signaling pathways in osteosarcoma cells is important to maintain cell viability and define in vitro, as well as in vivo chemosensitivity to the mTOR inhibitor Rapamycin. Sensitivity of osteosarcoma cells to Rapamycin is dependent on the relative phosphorylation of STAT3 at Y705. REFERENCES 1Ritu Bansal, Saddam Hussain, Upasana Bedi Chanana, Deepa Bisht, Isha Goel and Rohini Muthuswami. SMARCAL1, the annealing helicase and the transcriptional co-regulator. e304518 IUBMB Life. 2020, 72, 2080– 2096. 2Yi-tian Wang, Fan Tang, Xin Hu, Chuan-xi Zheng, Tao-jun Gong, Yong Zhou, Yi Luo and Li Min. Role of crosstalk between STAT3 and mTOR signaling in driving sensitivity to chemotherapy in osteosarcoma cell lines. IUBMB Life. 2020, 72, 2146– 2153. Volume72, Issue10October 2020Pages 2064-2064 ReferencesRelatedInformation