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BioFactorsVolume 46, Issue 6 p. 873-873 ISSUE HIGHLIGHTSFree Access ISSUE HIGHLIGHTS First published: 20 December 2020 https://doi.org/10.1002/biof.1698AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 874 Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells Simin Sharifi, Farzin Arablouye Moghaddam, Atefeh Abedi, Solmaz Maleki Dizaj, Shahin Ahmadian, Elaheh Dalir Abdolahinia, Seyed Mahdi Hosseiniyan Khatibi and Mohammad Samiei Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditionalmedicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation andmineralization of stem cells can be the result of specific bioactive compounds fromplants. One of the most appealing choices for therapy can be mesenchymal stem cells (MSCs) because it has a great capability of self-renewal and differentiation into three descendants, namely, endoderm, mesoderm, and ectoderm. Stem cell gives us the glad tidings of great advances in tissue regeneration and transplantation field for treatment of diseases. Using plant bioactive phytochemicals also holds tremendous promises in treating diseases such as osteoporosis. The purpose of the present review article thus is to investigate what are the roles and consequences of phytochemicals on osteogenic differentiation of MSCs. 894 An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells Manoj Kumar, Rishi Kumar Jaiswal, Pramod K. Yadava and Rana P. Singh Poly (ADP-ribose) polymerase (PARP) is a superfamily of 18 proteins characterized by the PARP homology domain, the catalytic domain. This catalytic domain helps in the ADP-ribosylation of various acceptor proteins using nicotinamide adenine dinucleotide (NAD+) as a donor for ADP-ribose. PARP-1 and PARP-2 carry out 80% of poly-ADP-ribosylation of cellular protein. Hence, their combined knockout results in embryonic lethality of mice. PARP-1 consists of three major domains, namely, DNA binding domain, automodification domain, and a catalytic domain. These domains further consist of subdomains and motifs, which helps PARP- 1 in a diverse function. PARP-1 is mainly involved in DNA damage detection and repair, but emerging evidence suggests its role in many other functions such as DNA synthesis, replication, apoptosis, necrosis, and cancer progression. Herein, we review the current state of the PARP-1 role in DNA damage repair and other biological processes including epithelial to mesenchymal transition (EMT). We have also observed the role of PARP-1 in modulating EMT regulators like E-cadherin, Vimentin, Claudin-1, Snail, Smad-4, Twist-1, and β- catenin. Here, we have also attempted to relate the role of PARP-1 in EMT of cancer cells. 906 Medicinal plants and bioactive natural compounds as inhibitors of HMG-CoA reductase: A literature review Atena Mahdavi, Mohammad Bagherniya, Omid Fakheran, Željko Reiner, Suowen Xu and Amirhossein Sahebkar Cardiovascular diseases (CVDs) are one of the most important causes for mortality worldwide. Elevated levels of total cholesterol, and particularly LDL-cholesterol (LDL-C) are the main risk factor for acute myocardial infarction (AMI) and ischemic heart disease. The risk of CVDs could be reduced by decreasing the elevated cholesterol levels. β-hydroxy β-methylglutaryl-CoA reductase (HMGCoAR) is the primary and rate-limiting enzyme in the cholesterol biosynthesis pathway. Recently, the crucial role of nutraceuticals in maintaining normal physiological function was established. Nutraceuticals play an important role in preventing several non-communicable diseases such as obesity, CVDs, cancer, diabetes, and reducing hyperlipidemia. Although the effect of nutraceuticals and herbal medicine on CVDs and dyslipidemia was previously investigated thoroughly, the effect of these natural products on HMGCoAR as one of the important enzymes involved in CVDs etiopathogenesis has not yet been investigated. Therefore, the major aim of this paper was to review the effects of nutraceuticals and medicinal plants on HMGCoAR. Results indicate that different types of natural foods, isolated nutrients, herbal products, and dietary supplements as nutraceuticals decrease the expression and activity of HMGCoAR. This review shows that medicinal plants and nutraceuticals could be used to decrease HMGCoAR activity as accessible and convenient and economical natural compounds to prevent dyslipidemia and CVDs. REFERENCES 1Simin Sharifi, Farzin Arablouye Moghaddam, Atefeh Abedi, Solmaz Maleki Dizaj, Shahin Ahmadian, Elaheh Dalir Abdolahinia, Seyed Mahdi Hosseiniyan Khatibi and Mohammad Samiei. Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells. BioFactors. 2020; 46: 874- 893. 2Manoj Kumar, Rishi Kumar Jaiswal, Pramod K. Yadava and Rana P. Singh. An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells. BioFactors. 2020; 46: 894- 905. 3Atena Mahdavi, Mohammad Bagherniya, Omid Fakheran, Željko Reiner, Suowen Xu and Amirhossein Sahebkar. Medicinal plants and bioactive natural compounds as inhibitors of HMG-CoA reductase: A literature review. BioFactors. 2020; 46: 906- 926. Volume46, Issue6November/December 2020Pages 873-873 ReferencesRelatedInformation