Issue Cover (September 2018)

Abstract

Journal of NeurochemistryVolume 146, Issue 5 Issue CoverFree Access Issue Cover (September 2018) First published: 21 September 2018 https://doi.org/10.1111/jnc.14191 Read the full article: ‘Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells’ by A. Elkordy, E. Mishima, K. Niizuma, Y. Akiyama, M. Fujimura, T. Tominaga, T. Abe (J. Neurochem. 2018, vol. 146(5), pp. 560–569) on doi: 10.1111/jnc.14321 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Front cover: Background: Transfer RNA (tRNA) plays a role in stress response programs involved in neurological diseases. Under cell stress conditions, intracellular tRNA is cleaved by a specific ribonuclease, angiogenin, generating tRNA-derived stress-induced RNA (tiRNA), which has potential cell protective effects. However, tiRNA generation in neuronal cells has not been fully elucidated. Main findings: We found that tiRNA is induced by various cell stresses, including in vitro ischemia-reperfusion, via angiogenin-mediated mechanism in PC12 neuronal cell. Implication: Detection of tiRNA could be used as a potential cell damage marker in neuronal cells. Image content: Cover image shows a micrographic image of the PC12 cells. Read the full article ‘Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells’ by A. Elkordy, E. Mishima, K. Niizuma, Y. Akiyama, M. Fujimura, T. Tominaga, T. Abe (J. Neurochem. 2018, vol. 146(5), pp. 560–569) on doi: 10.1111/jnc.14321 Volume146, Issue5September 2018 RelatedInformation