Abstract
Front cover: Background: Fibroblast Growth Factor 2 (FGF2) gene expression has been demonstrated to be altered in brain regions of major depressive disorder (MDD) patients, and FGF2 has been shown to have anti-depressive effects in animal models of depression. Main finding: Glutamatergic neurons (iNeurons) were derived from human stem cells using the stable integration of a human NEUROG2 transgene. This system was used to demonstrate that FGF2 enhances glutamatergic transmission in these iNeurons. Several FGF2-regulated genes were identified mediating this enhancement including NRNX3 and SYT2. Implication: Since several of these genes have been implicated in MDD previously, these results will provide the basis for more mechanistic studies of the role of FGF2 in MDD. Image Content: This image shows iNeurons derived from human stem cells that have been labeled with ubiquitous mCherry (red) expression and GCamp6f (green) as a reporter of calcium activity. A high ratio of green to red fluorescence is indicative of high neuronal calcium levels. Read the full article ‘Fibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons’ by S. Gupta, T. M-Redmond, F. Meng, A. Tidball, H. Akil, S. Watson, J. M. Parent, M. Uhler (J. Neurochem. 2018, vol. 145 (3), pp. 188–203) on doi: 10.1111/jnc.14255
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