Abstract
Front cover: The gut hormone ghrelin is neuroprotective in Parkinson's Disease. However, ghrelin exists in two distinctive isoforms (acylated and des-acylated ghrelin). This representative image shows dopamine neurons (green) and microglial activation (red) in response to the MPTP model of Parkinson's Disease. We show that acylated ghrelin is the isoform responsible for in vivo neuroprotection of ghrelin in the MPTP model of Parkinson's Disease by minimising dopamine cell loss and attenuating glial activation. Overall, we show that acylated ghrelin is an ideal therapeutic target to reduce Parkinson's Disease progression. Read the full article ‘Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease’ by J. A. Bayliss, M. Lemus, V. V. Santos, M. Deo, J. D. Elsworth and Z. B. Andrews (J. Neurochem. 2016, vol. 137 (3), pp. 460-471) on doi: 10.1111/jnc.13576
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