Issue Cover (March 2021)

Abstract

Journal of NeurochemistryVolume 156, Issue 6 Issue CoverFree Access Issue Cover (March 2021) First published: 01 April 2021 https://doi.org/10.1111/jnc.15056 Read the full article: ‘Necrostatin-1 prevents the proapoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 from integration into mitochondria’ by J. Mu, J. Weng, C. Yang, T. Guan, L. Deng, M. Li, G. Zhang, J. Kong (J. Neurochem. 2021, vol. 156 (6), pp. 929–942) on doi:10.1111/jnc.14993 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Front cover: Necrostatin-1 (Nec-1) has been shown to inhibit necroptosis. The mitochondrial protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) activates a type of caspase-independent cell death that is similar to necroptosis. Here we show that Nec-1 is protective against death of neurons and oligodendrocytes in traumatic brain injury (TBI) in mice and in ischemic stroke in rats by inhibiting BNIP3; Nec-1 prevents BNIP3 from integration into mitochondria to block the BNIP3 cell death pathway. The data suggest that Nec-1 is a novel inhibitor for BNIP3. Image Content: Nec-1 preserves structural integrity of axons and myelin sheathes against TBI-induced injuries in rats. Electron microscopy reveals that the ultrastructure of axons and myelin sheathes is largely preserved by Nec-1. The animals received intracerebroventricular injection of Nec-1 right after TBI and were euthanized after anesthesia 7 days after TBI. Read the full article ‘Necrostatin-1 prevents the proapoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 from integration into mitochondria’ by J. Mu, J. Weng, C. Yang, T. Guan, L. Deng, M. Li, G. Zhang, J. Kong (J. Neurochem. 2021, vol. 156 (6), pp. 929–942) on doi:10.1111/jnc.14993 Volume156, Issue6March 2021 RelatedInformation