Issue Cover (June 2019)

Abstract

Journal of NeurochemistryVolume 149, Issue 6 Issue CoverFree Access Issue Cover (June 2019) First published: 24 June 2019 https://doi.org/10.1111/jnc.14510 Read the full article: ‘FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein’ by Z. S. Chen, A. K. Y. Wong, T. C. Cheng, A. C. Koon, H. Y. E. Chan (J. Neurochem. 2019, vol. 149 (6), pp. 781–798) on doi: 10.1111/jnc.14669 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Front cover:The expansion of glutamine-coding CAG repeats in the disease genes causes the formation of polyglutamine (polyQ) protein aggregates, which impairs a range of cellular compartments including the ubiquitin-proteasome system and contributes to polyQ pathologies. F-box proteins are the substrate receptors of the Cullin-1 E3 ubiquitin ligase complexes. A genetic modifier screen identified Drosophila F-box gene F-box involved in polyQ pathogenesis (FipoQ) as a novel suppressor of polyQ degeneration. We further demonstrated such suppression is achieved via modifying ubiquitination and solubility of expanded polyQ proteins, and F-box only protein 33 (FBXO33), human counterpart of FipoQ, exerts similar functions. These findings taken together describe a novel role of F-box proteins in polyQ diseases and provide better mechanistic understanding of polyQ pathogenesis. Image Content: An immunofluorescent confocal micrograph showing cells co-expressing expanded SCA3tr-Q78 (green) and FBXO33 (red) proteins. SCA3tr-Q78 protein aggregates are identified as punctate green signals within the cell nucleus. Cell nuclei (blue) were stained with Hoechst 33342. Read the full article ‘FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein’ by Z. S. Chen, A. K. Y. Wong, T. C. Cheng, A. C. Koon, H. Y. E. Chan (J. Neurochem. 2019, vol. 149 (6), pp. 781–798) on doi: 10.1111/jnc.14669 Volume149, Issue6June 2019 RelatedInformation