Issue Cover (August 2018)

Abstract

Journal of NeurochemistryVolume 146, Issue 3 Issue CoverFree Access Issue Cover (August 2018) First published: 30 July 2018 https://doi.org/10.1111/jnc.14187 Read the full article: ‘Cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens shell inhibits cocaine-induced locomotor sensitization to transient over-expression of α-Ca2+/calmodulin-dependent protein kinase II’ by L. Xiong, Q. Meng, X. Sun, X. Lu, Q. Fu, Q. Peng, J. Yang, K.-W. Oh, Z. Hu (J. Neurochem. 2018, vol. 146 (3), pp. 289–303) on doi: 10.1111/jnc.14289 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Front cover: Background: Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter that attenuates cocaine-induced locomotor activity when injected into the nucleus accumbens (NAc). Main findings: Here we show that cocaine administration enhances the phosphorylated Ca2+/calmodulin-dependent protein kinaseIIα (pCaMKIIα)- D3 dopamine receptor (D3R) interaction in the NAc shell, while intra-accumbal injection of CART peptide decreases cocaine-induced locomotor sensitization. Implication: Therefore, we propose that CART peptide exerts its inhibitory effect on cocaine-induced locomotor sensitization via inhibition of the pCaMKIIα-D3R interaction, calcium influx and D3R signaling in the NAc shell, which could provide new evidence for the application of CART peptide to treat cocaine-induced behavioral sensitivity. Image content: The image shows a immunofluorescence image of CaMKIIα-GFP-overexpressing NAc neurons (green) stained with pCaMKIIα antibodies (red), nuclei (DAPI, blue). Read the full article ‘Cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens shell inhibits cocaine-induced locomotor sensitization to transient over-expression of α-Ca2+/calmodulin-dependent protein kinase II’ by L. Xiong, Q. Meng, X. Sun, X. Lu, Q. Fu, Q. Peng, J. Yang, K.-W. Oh, Z. Hu (J. Neurochem. 2018, vol. 146 (3), pp. 289–303) on doi: 10.1111/jnc.14289 Volume146, Issue3August 2018 RelatedInformation