Abstract
Aim: This study aimed to determine the possible chromosomal abnormalities in leukemia patients who were diagnosed and treated in Hematology Clinics of Internal Medicine Department and Pediatric Hematology Clinic of Pediatry Deparment in Suleyman Demirel University Research Hospital.Material and Method: In study 29 patients of whom 12 in post-chemotherapeutic period, 17 in remission periods with any stage of treatment in leukemia group and 30 age-and gender-matched control person were evaluated cytogenetically. Results: Of the leukemia group; 15 had acute lymphoblastic leukemia, 5 had chronic lymphoblastic leukemia, 5 had chronic myeloid leukemia and 4 had acute myeloid leukemia. Four out of 15 patients with acute lymphoblastic leukemia, 1 of 5 with chronic lymphoblastic leukemia and 1 of 5 with chronic myeloid leukemia had different cytogenetic aberrations. t(9;22)(q34;q11) was detected in two patients, one with chronic myeloid leukemia and the other with chronic lymphoblastic leukemia.; del(17q), inv(9), inv(1), and t(12;15) are found in four ALL cases respectively. Conventional cytogenetic analysis of peripheral blood is fundamental for advanced genetic study. Key words: Leukemia, GTG banding, Chemotherapy, Chromosome, Peripheric blood.
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