Abstract
The “one-pot” homogeneous hydrogenation of γ-butyrolactone and succinic or fumaric acid to 1,4-butandiol, have been successfully realized in the presence of the catalytic system [Ru(acac) 3]/triphos] [triphos:MeC(CH 2PPh 2) 3]. The influence of some reaction parameters on the regioselectivity and the rate of the reaction were investigated. The study was then extended to the “one-pot” synthesis of isotopomeric 1,4-butandiols by deuteration of the appropriate substrates in a deuterated solvent. 1,4-butandiol-d 8, which was fully characterized, was obtained with 96% yield and 100% isotopomeric selectivity. A mechanism was proposed to rationalize the role of catalyst, solvent and deuterium distribution.
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