Abstract
Another foot forward: Isotope-coded affinity tag (ICAT) reagents are versatile probes for footprinting dynamic protein structure. To render ICAT footprinting effective, a series of ICAT reagents with alkylation rates that span five orders of magnitude was designed. With this toolkit, an unprecedented range of Cys residues can be footprinted, including those deeply buried in the protein core and those involved in protein–protein interactions of modest affinity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
