Abstract
Due to the rise of antifungal resistance and emerging fungal pathogens, there is an increasing need to find efficient treatment for Candida infections. This study determined the inhibition of combinational therapy against two of the most frequently found Candida strains in the oral cavity, C. albicans and C. krusei. Minimal inhibitory concentrations of amphotericin B, fluconazole, and 5-fluorocytosine and the effect of combination therapy were determined for these strains by isothermal microcalorimetry. Fluconazole was the most effective antimicrobial at the concentrations included. Additionally, adding fluconazole to the other two antimicrobials rapidly inhibited the growth of both Candida species. Thus, the microcalorimetric technique is not only well-fitted for in vitro testing of drug combinations for treatment, but also for applications in drug development.
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