Abstract
Batch experimental studies were carried out on the adsorption of paclitaxel onto Sylopute, with the data then being fit to the Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models. A comparison of the results revealed that, among the four isotherm models considered, the Freundlich isotherm model could account for the adsorption isotherm data with the highest accuracy. From the analysis of adsorption isotherms, it was found that the adsorption capacity increased with an increasing temperature and the adsorption of paclitaxel onto Sylopute was favourable. The obtained kinetics data for paclitaxel adsorption with Sylopute agreed well with the pseudo-second-order model. In addition, according to the intraparticle diffusion model, intraparticle diffusion played a dominant role in paclitaxel adsorption. Thermodynamic parameters revealed the endothermic, irreversible, and nonspontaneous nature of the adsorption.
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