Abstract
Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities. Berberine was identified as a major component but its analogue, pseudoberberine, was isolated for the first time from this plant. As far as bisbenzylisoquinolines are concerned, thalfoetidine was also isolated and, besides, its nor- derivative, northalfoetidine, was identified as a new compound. Previously isolated alkaloids from Thalictrum species such as northalidasine, northalrugosidine, thaligosidine, thalicberine, thaliglucinone, preocoteine, O-methylcassythine and armepavine were newly described in the roots of T. flavum. Tertiary isoquinolines, and particularly bisbenzylisoquinolines, were found to be leishmanicidal against L. major. Thalfoetidine appeared as the most potent but its new nor- derivative northalfoetidine, as well as northalidasine, were of particular interest due to the fact that their potential leishmanicidal activity was not associated to a strong cytotoxicity.
Highlights
Distributed all over the world, Thalictrum species (Ranunculaceae) mainly grow in the temperate and cold zones of both hemispheres
We describe the alkaloids of T. flavum L., together with their antiparasitic potential
While complex and pharmacologically active dimeric alkaloids such as bisbenzylisoquinolines were already isolated from T. flavum L., structurally simpler isoquinolines were extracted from this species [17]
Summary
Jacqueline Ropivia 1 †, Séverine Derbré 1,*, Caroline Rouger 1, Fabrice Pagniez 2, Patrice Le Pape 2 and Pascal Richomme 1. Laboratoire des Substances d’Origine Naturelle et Analogues Structuraux, UPRES-EA 921, IFR
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