Abstract
A phytochemical investigation of Thalictrum glandulosissimum (Finet et Gagnep.) W. T. Wang & S. H. Wang (Ranunculaceae), a species used medicinally in China, led to the isolation and identification of nine isoquinoline alkaloids, including four protoberberines (compounds 1–4), a protopine-type alkaloid (5), a bridge-protoberberine-type alkaloid (6), and three bis-benzylisoquinolines (7–9). Among them, thalictricavine (4) and valachine (6) are reported for the first time in the genus Thalictrum. Furthermore, three alkaloids (7–9) have not previously been isolated from this species. In addition, network analysis was carried out to explore their possible chemotaxonomic values among species in the Thalictrum genus. The results showed that some of these compounds such as thalictricavine (4) and valachine (6) showed limited distribution in the genus, which could help to narrow species identification to T. glandulosissimum where other phenotypic characters are limited.
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