Abstract
A single intraperitoneal administration of 1-(3,4-dihydroxyphenyl)-2-isopropylaminoethanol (isoproterenol) causes a marked stimulation of DNA synthesis and cell division in parotids of mice. An analog of isoproterenol, 1-phenyl-2-isopropylaminoethanol, can be hydroxylated by mouse liver in positions 3 and 4 of the phenyl ring, confirming the presence in mouse liver of hydroxylating enzymes, presumably an arylhydroxylase. When hydroxylated, 1-phenyl-2-isopropylaminoethanol is as active as isoproterenol in stimulating DNA synthesis in mouse parotids. However, the hydroxylation of 1-phenyl-2-isopropylaminoethanol is markedly inhibited both in vivo and in vitro by ethanol. When the compound is injected, dissolved in ethanol, it has no effect on the stimulation of DNA synthesis in mouse parotid. The results clearly indicate that hydroxyl groups are a necessary requirement for the ability of isoproterenol and/or its analogs to induce DNA synthesis and cell division in mouse salivary glands.
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