Abstract
ABSTRACTBenzo[a]pyrene (BaP), a carcinogen, leads to the severe liver injury. Isoorientin (ISO), a natural flavonoid, is known for its bioactivities, including anti-oxidation, anti-inflammation, and so on. However, there is no report on the effects of ISO on liver injury induced by BaP. The present study demonstrated that ISO treatment could relieve BaP-caused autophagic and pyroptotic injury in HL-7702 human hepatocyte and male BALB/c mice by down-regulating the numbers of autophagosomes, the mRNA expression of LC3 II and Beclin-1, and the levels of pyroptotic characteristic indices. Histopathology stained also confirmed that ISO could suppress the BaP-induced liver injury. Meanwhile, ISO was able to improve the liver function, and remarkably (p < 0.01) ameliorate hepatic oxidative injury by enhancing antioxidant enzymes activities (T-SOD, GSH-px) and reducing the levels of MDA and H2O2. In conclusion, ISO possesses the positive inhibitive effects on BaP-induced the autophagic and pyroptotic liver injury in vitro and vivo.
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