Isonicotinic acid hydrazide and urethan carcinogenesis in suckling SWR mice

Abstract

Five i.p. injections of 1 mg urethan/g body weight on alternate days administered to 10-day old SWR mice resulted in the development of thymic lymphosarcomas in 60 % and of lung adenomas in nearly 100 % of the animals, irrespective of sex. Concurrent treatment with isonicotinic acid hydrazide (INH), 0.1 mg/g body weight, administered five times on alternate days starting at 9 days of age, did not modify the carcinogenic effect of urethan. The treatment with INH alone did not induce a higher tumor incidence than in untreated controls.