Abstract
Psychosis is a state of altered behaviour and mentation and it is not common in children. Isoniazid is a commonly used drug in the treatment and prophylaxis of tuberculosis. It may cause psychosis if overdosed but rarely with usual recommended doses. We report a case of drug induced psychosis secondary to isoniazid intake in a seven years old boy, who exhibited psychotic features about 10 days after the commencement of anti-TB combination drugs (Directly Observed Treatment Shortcourse) containing Isoniazid. This patient had no past medical or family history of mental illness. Drug induced psychosis was a possibility, and the responsible drug (isoniazid) was stopped. He improved following the withdrawal of isoniazid. Isoniazid psychosis is a major complication as iatrogenic psychiatric complications can greatly impact the patients’ quality of life, which if recognised early can be effectively treated.
Highlights
Tuberculosis (TB) continues to be an important public health problem.[1]
Isonicotinic acid hydrazide (INH), known as Isoniazid, has been in use since it was introduced by Robitzek in 1952 because of its potency, safety and low cost.[2]
Isoniazid was reintroduced at low doses and patient developed symptoms of psychosis again. This confirmed the diagnosis of isoniazid induced psychosis
Summary
Tuberculosis (TB) continues to be an important public health problem.[1]. The conventional approaches employed to fight TB are good nutrition, Bacillus Calmette-Guerin (BCG). He was the first child in a family of four children and there was no past medical or family history of mental illness. Planned extubation was done after 72 hours of admission which was successful and child was kept on oxygen. He was diagnosed as a case of disseminated tuberculosis. Isoniazid was reintroduced at low doses and patient developed symptoms of psychosis again. This confirmed the diagnosis of isoniazid induced psychosis
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